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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Benzimidazole analogs inhibit human herpesvirus 6.

Several benzimidazole nucleoside analogs, including 1H-β-d-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-l-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two l-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.[1]

References

  1. Benzimidazole analogs inhibit human herpesvirus 6. Prichard, M.N., Frederick, S.L., Daily, S., Borysko, K.Z., Townsend, L.B., Drach, J.C., Kern, E.R. Antimicrob. Agents Chemother. (2011) [Pubmed]
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