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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Genetic recombination in the alpha 2 domain of the E alpha chain yields an Ed molecule with altered T cell activation.

We have used a novel T cell selection strategy to isolate a mutant of an H-2d/f murine macrophage line defective in its ability to present antigen to some Ed-restricted helper T cells. This mutant has an amino acid substitution in the alpha 2 domain of the Ed molecule. The mutation changes the sequence at codon 177 from ACC to CAC, which results in a threonine to histidine substitution and appears to be the first in vitro mutation to have arisen by genetic recombination. Even though the mutation is distal to the proposed antigen-binding groove, it affects antigen presentation, presumably by altering the scaffolding for the antigen-binding groove. This type of mutant might not be readily isolated using other selection techniques.[1]

References

  1. Genetic recombination in the alpha 2 domain of the E alpha chain yields an Ed molecule with altered T cell activation. Chang, M.Y., Kowal, C., Marzullo, L.R., Briner, T.J., Gefter, M.L., Diamond, B. Eur. J. Immunol. (1990) [Pubmed]
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