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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.[1]

References

  1. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Rosado, I.V., Langevin, F., Crossan, G.P., Takata, M., Patel, K.J. Nat. Struct. Mol. Biol. (2011) [Pubmed]
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