- Overall Survival Benefit With Lapatinib in Combination With Trastuzumab for Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Final Results From the EGF104900 Study. Blackwell, K.L., Burstein, H.J., Storniolo, A.M., Rugo, H.S., Sledge, G., Aktan, G., Ellis, C., Florance, A., Vukelja, S., Bischoff, J., Baselga, J., O'Shaughnessy, J. J. Clin. Oncol. (2012)