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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Purification of rabbit bone morphogenetic protein derived from bone, dentin, and wound tissue after tooth extraction.

Bone morphogenetic protein ( BMP) was extracted from bone matrix, dentin matrix, and wound tissue after tooth extraction in rabbits, and purified. These purified fractions were shown to be homogeneous by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis (SDS-PAGE), and induced new bone in situ in 3 weeks when implanted into the calf muscles of Wistar rats. The dentin matrix-derived BMP was different from the other two types in molecular weight and the properties revealed in the process of purification. However, each tissue-derived BMP was shown to induce new bone growth in a bioassay of xenogenic implantation. For this reason, BMP is thought to have subunits with certain commonalities in different tissue.[1]

References

  1. Purification of rabbit bone morphogenetic protein derived from bone, dentin, and wound tissue after tooth extraction. Bessho, K., Tagawa, T., Murata, M. J. Oral Maxillofac. Surg. (1990) [Pubmed]
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