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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response.

The B6 anti-bm6 allospecific CTL response is strictly dependent on CD4+ cells when using LPS blasts as stimulator cells. Altering the N-linked carbohydrates on stimulator cells by use of the N-linked trimming glycosidase inhibitors 1-deoxymannojirimycin and swainsonine, or by treatment with bacterial neuraminidase, results in a restoration of the B6 anti-bm6 response in the absence of CD4+ cells. The extent of restoration is inversely correlated with the number of sialic acids present on N-linked glycans of stimulator cells.[1]

References

  1. N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. Neefjes, J.J., De Bruijn, M.L., Boog, C.J., Nieland, J.D., Boes, J., Melief, C.J., Ploegh, H.L. J. Exp. Med. (1990) [Pubmed]
 
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