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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Relationship between the pharmacokinetics and toxicity of mitozolomide.

The cytotoxic drug mitozolomide has been found to cause unpredictably severe thrombocytopenia during phase I and II clinical trials. In an attempt to relate dose and pharmacokinetic parameters to toxicity, we measured plasma concentrations of mitozolomide in 14 patients with a range of malignancies. There were significant correlations (Spearman rank correlation test) between drug clearance and AUC and white blood cell nadir. The pharmacokinetic and toxicity data were not normally distributed; therefore, it was not possible to construct predictive nomograms for toxicity based on linear regression analysis.[1]

References

  1. Relationship between the pharmacokinetics and toxicity of mitozolomide. Kerr, D.J., Slack, J.A., Secrett, P., Stevens, M.F., Blackledge, G.R., Bradley, C., Kaye, S.B. Cancer Chemother. Pharmacol. (1990) [Pubmed]
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