Identical D region sequences expressed by murine monoclonal antibodies specific for a human tumor-associated antigen.
Sequence analysis has revealed significant structural similarities among murine mAb specific for the human tumor-associated Ag GA733. Antibodies generated in independent immunizations, either with Ag-positive tumor cells or with anti-idiotypic antibodies produced by immunization of goats with a GA733-specific antibody, all use members of the same gene families; remarkably, they also express identical amino acid sequences in their H chain CDR3. Inasmuch as this region normally exhibits considerable sequence variability, the identity displayed by the antibodies indicates a requirement for this particular sequence in the generation of their specificity for the GA733 antigen. Moreover, this homology suggests that the antibodies recognize a common determinant on the Ag, and that the polyclonal anti-idiotypic antibodies can functionally mimic the Ag at the level of the structure of the Ag-specific antibody that is induced.[1]References
- Identical D region sequences expressed by murine monoclonal antibodies specific for a human tumor-associated antigen. Caton, A.J., Herlyn, D., Ross, A.H., Koprowski, H. J. Immunol. (1990) [Pubmed]
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