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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

An experimental model of death from anaphylactic shock with compound 48/80 and postmortem changes in levels of histamine in blood.

The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect closely resembling the immuno-reaction, resulted in reliable death in a short time. The animals that died rapidly after the injection of compound 48/80, were found to have large increases in levels of histamine and 1-methylhistamine soon after the administration. These results were similar to the results of injecting histamine exogenously. On the other hand, the animals that died after a longer time showed no increases in levels of those amines within about 24 h, but 24 hours after death histamine levels were only increased tremendously without rise in 1-MHA levels. These phenomena closely resembled those in the control animals that were treated with overdoses of Nembutal.[1]

References

  1. An experimental model of death from anaphylactic shock with compound 48/80 and postmortem changes in levels of histamine in blood. Hieda, Y., Kageura, M., Hara, K., Takamoto, M., Fukuma, Y., Kashimura, S. Forensic Sci. Int. (1990) [Pubmed]
 
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