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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Immortalized retinal neurons derived from SV40 T-antigen-induced tumors in transgenic mice.

Immortalized retinal neurons have been established in tissue culture from retinal tumors arising in transgenic mice. The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase ( PNMT) gene in order to target oncogene expression to adrenergic cell types. The retinal cultures contain a proliferation population of T-antigen-positive cells with a neuronal morphology that includes formation of extensive neuritic processes. We identified the cells as amacrine-derived neurons by immunofluorescence using the cell-specific monoclonal antibodies VC1.1 and HPC-1. The cells also express all three neurofilament subunits and GAP-43. These results indicate that CNS neurons can be transformed in transgenic animals to generate cultured cells with many properties of mature neurons.[1]

References

  1. Immortalized retinal neurons derived from SV40 T-antigen-induced tumors in transgenic mice. Hammang, J.P., Baetge, E.E., Behringer, R.R., Brinster, R.L., Palmiter, R.D., Messing, A. Neuron (1990) [Pubmed]
 
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