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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen.

Two novel monosialogangliosides were isolated from rat spleen. The structures of the gangliosides (shown below, where NeuNGc is N-glycolylneuraminic acid) were characterized by compositional analysis, methylation analysis, hydrolyses with exoglycosidases, direct probe fast atom bombardment mass spectrometry, and proton nuclear magnetic resonance spectrometry. A novel structure common to both gangliosides was N-acetyllactosaminyl-GM1 LacN-GM1; where GM1 is II3NeuAc-GgOse4Cer), and this is the first paper to report the occurrence of a new group of gangliosides. [formula: see text] Furthermore, in a monosialoganglioside fraction of rat spleen, the occurrence of a ganglioside having two lactosamine units ( Gal alpha 1-3(Gal beta 1-4GlcNAc beta 1-3)2-GM1(NeuAc) (alpha Gal-(LacN)2-GM1] was suggested. These gangliosides have a unique structure, which includes the ganglio series ganglioside core and the extended modification characteristic of the lacto series.[1]


  1. Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen. Nohara, K., Suzuki, M., Inagaki, F., Ito, H., Kaya, K. J. Biol. Chem. (1990) [Pubmed]
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