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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Enhancement by interferon of chicken splenocyte natural killer cell activity against Marek's disease tumor cells.

A non-immune natural killer-type cell population (NK) from 6-to 12-week old chickens was able to kill MSB-1 Marek's disease (MD) tumor cells in vitro; as measured by the 51Cr-release cytotoxicity assay. Removal of T cells, B cells, adherent cells, or any combination of the three populations of cells did not result in diminished levels of cytotoxicity of the remaining spleen cells against MSB-1 cells. The cytotoxicity of chicken NK cells could be rapidly augmented by polyinosinic-polycytidylic acid (poly I:C) and by the Cal 11914 strain of Newcastle disease virus (NDV), but not by the TCND strain of NDV which is not an interferon (IFN) inducer, indicating that IFN play a role in augmentation of the NK activity in chickens.[1]

References

  1. Enhancement by interferon of chicken splenocyte natural killer cell activity against Marek's disease tumor cells. Ding, A.H., Lam, K.M. Vet. Immunol. Immunopathol. (1986) [Pubmed]
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