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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder.

To test the hypothesis that any change in urinary noradrenergic excretion accompanies drug-induced improvement in attention deficit disorder with hyperactivity, the authors gave pemoline (mean dose, 2.9 mg/kg of body weight) to 11 boys with this disorder in a 4-week open trial. Pemoline administration improved behavior but did not significantly change urinary catecholamine excretion. Serotonin excretion was unchanged, but phenylethylamine (PEA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly decreased. Clinical responders and nonresponders did not differ with respect to baseline urinary monoamine excretion or change in PEA and 5-HIAA excretion.[1]

References

  1. Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder. Zametkin, A.J., Linnoila, M., Karoum, F., Sallee, R. The American journal of psychiatry. (1986) [Pubmed]
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