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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

A radioimmunometric assay for the detection and characterization of lung cancer-associated antibodies in sera of lung cancer patients.

A radioimmunometric assay was developed from P3 lung carcinoma target cells to detect anti-lung cancer antibodies. Of 100 sera from lung cancer patients tested, 80 (80%) were positive. However, only 6/30 (20%) sera from cancer patients with other cancers, 1/25 (4%) of sera from patients with nonmalignant lung disease, and 0/20 sera from healthy donors were positive. Quantitative absorptions showed that sera from lung cancer patients cross-reacted with other lung cancers, gastrointestinal cancers, and/or fetal lung tissues, but not with breast carcinomas, melanomas, sarcomas, fetal skin, or normal lung tissues. Two lung cancer antigens were defined: LCA-1, which shared antigenic determinants with GI tumors and fetal lung tissues, and LCA-2, which showed cross-reactivity only with GI tumors.[1]

References

  1. A radioimmunometric assay for the detection and characterization of lung cancer-associated antibodies in sera of lung cancer patients. Hatzitheofilou, C., Kern, D.H., Gupta, R.K., Campbell, M.A., Morton, D.L. J. Surg. Res. (1987) [Pubmed]
 
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