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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Generation of competent virus in the REV helper cell line C3.

We have studied the generation of replication-competent virus in cultures of the helper cell line C3, which harbors a packaging-defective provirus derived from reticuloendotheliosis virus. We transfected the C3 line with a defective provirus encoding the chicken growth hormone gene and carrying the HSV-1 tk gene. The appearance of competent virus was assayed by infection of Spafas C/E CEF, monitoring reverse transcriptase activity, and rescue of the TKTU assayed on BRLtk- cells. Our results indicate that cultures of C3 producing TKTU can release viruses which have variable growth characteristics and which can remain latent in culture for extended periods of time.[1]

References

  1. Generation of competent virus in the REV helper cell line C3. Hu, S., Bruszewski, J., Nicolson, M., Tseng, J., Hsu, R.Y., Bosselman, R. Virology (1987) [Pubmed]
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