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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities.

Protein sequence analysis of a bovine brain phosphoinositide-specific phospholipase C ( PI-PLC; PLC-154) has permitted the isolation of a cDNA that appears to code for this protein. Transient expression of this cDNA in COS-1 cells demonstrates that the cDNA encodes a functional phospholipase C that migrates at approximately 150,000 daltons. A transcript of approximately 7 kb is observed in RNA derived from bovine brain and a related transcript of the same size is present in certain human cell lines. Southern blot analysis indicates that one or possibly two genes hybridize with a PLC-154 probe. Regions of homology between PLC-154 and the previously described PLC-148 allow the assignment of a putative catalytic domain to the central region of PLC-154.[1]

References

  1. Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities. Katan, M., Kriz, R.W., Totty, N., Philp, R., Meldrum, E., Aldape, R.A., Knopf, J.L., Parker, P.J. Cell (1988) [Pubmed]
 
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