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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Noninterference of isosulfan blue on estrogen-receptor activity.

Because a 1% sterile solution of methylene blue used for occult breast tumor localization has been shown to interfere with the estrogen-receptor protein ( ERP) binding-capacity assay, isosulfan blue in a 1% injection was studied as a potential alternate stain. Cytosols derived from ERP-positive lyophilized powders and human breast tissue were evaluated with and without varying levels of treatment with isosulfan blue. No modification of the ERP-specific binding capacity was found with this stain. The use of isosulfan blue for localization of occult breast tumor is suggested when an ERP binding capacity assay is anticipated.[1]

References

  1. Noninterference of isosulfan blue on estrogen-receptor activity. Hirsch, J.I., Banks, W.L., Sullivan, J.S., Horsley, J.S. Radiology. (1989) [Pubmed]
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