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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas.

The effects of sodium salts of medium-chain fatty acids, caprylate and caprate, on the penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas in vitro were examined. Sodium caprylate (0.5 and 1% 2/v) marginally increased the corneal penetration of 6-carboxyfluorescein, a hydrophilic compound. However, it did not change the corneal penetration of FITC-dextran (mol.wt 4000). Sodium caprate (0.5 and 1% w/v) markedly increased the corneal penetration of these compounds.[1]

References

  1. Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas. Morimoto, K., Nakamura, T., Morisaka, K. Archives internationales de pharmacodynamie et de thérapie. (1989) [Pubmed]
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