Regulatory role for GTP-binding proteins in endocytosis.
Guanosine 5'-triphosphate (GTP)-binding proteins have been implicated in the transport of newly synthesized proteins along the secretory pathway of yeast and mammalian cells. Early vesicle fusion events that follow receptor-mediated endocytosis as measured by three in vitro assays were blocked by guanosine 5'-O-(3-thiotriphosphate) and aluminum fluoride. The effect was specific for guanosine nucleotides and depended on the presence of cytosolic factors. Thus, GTP-binding proteins may also have a role in the transport of molecules along the endocytic pathway.[1]References
- Regulatory role for GTP-binding proteins in endocytosis. Mayorga, L.S., Diaz, R., Stahl, P.D. Science (1989) [Pubmed]
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