The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Assessment of the systemic distribution and toxicity of glutaraldehyde as a pulpotomy agent.

The systemic distribution of glutaraldehyde (GA) from a pulpotomized tooth of a rat was estimated to be 40 nanomoles or 25% of the applied dose. Metabolic studies disclosed that GA was eliminated in urine and expired gases; 90% was cleared from body tissues in 3 days. To evaluate the toxicity of GA, doses 500x greater than that systemically distributed from a pulpotomy site were infused into the jugular veins of rats. Twenty-four hours postinfusion the rats were evaluated in vivo for physiologic changes or sacrificed for biochemical and histologic evaluation of harvested tissues. Only one of the assays, a physiologic parameter, was altered by the 500x dose. Considering the relatively large dose administered and the limited effects, we conclude that GA would not be toxic when used as a pulpotomy agent.[1]

References

  1. Assessment of the systemic distribution and toxicity of glutaraldehyde as a pulpotomy agent. Ranly, D.M., Horn, D., Hubbard, G.B. Pediatric dentistry. (1989) [Pubmed]
 
WikiGenes - Universities