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N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?

Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well-developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. Several specific antagonists, including MK-801, dextrorphan, dextromethorphan, and ketamine, have already been used at low doses in humans for other indications and are potential candidates for Phase I clinical trials.[1]


  1. N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia? Albers, G.W., Goldberg, M.P., Choi, D.W. Ann. Neurol. (1989) [Pubmed]
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