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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Constitutive mutants in the yeast pheromone response: ordered function of the gene products.

The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.[1]

References

  1. Constitutive mutants in the yeast pheromone response: ordered function of the gene products. Blinder, D., Bouvier, S., Jenness, D.D. Cell (1989) [Pubmed]
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