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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.

The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.[1]

References

  1. Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891. Franceschi, G., Perrone, E., Alpegiani, M., Bedeschi, A., Battistini, C., Zarini, F., Della Bruna, C. J. Antimicrob. Chemother. (1989) [Pubmed]
 
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