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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.

Mutagenesis of mouse hepatitis virus with 5-azacytidine or 5-fluorouracil yielded several temperature-sensitive mutants. Mutants have been isolated that dramatically enhance the production of demyelinating disease over that previously noted with the wild-type virus. This reproducible model should now make possible the precise elucidation of the pathogenic mechanism and molecular basis of this virus-induced demyelination.[1]

References

  1. Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination. Haspel, M.V., Lampert, P.W., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
 
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