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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tardive dyskinesia and steady-state serum levels of thiothixene.

The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.[1]

References

  1. Tardive dyskinesia and steady-state serum levels of thiothixene. Yesavage, J.A., Tanke, E.D., Sheikh, J.I. Arch. Gen. Psychiatry (1987) [Pubmed]
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