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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox.

During postembryonic development in C. elegans, posterior-specific pattern formation requires the gene mab-5. Within the posterior body region, mab-5 activity controls epidermal, neuronal, and mesodermal cell differentiation, and also the direction of cell migration. Here, we show that mab-5 RNA is localized in the posterior body region, indicating that mab-5 activity is targeted to posterior cells, at least in part, by a mechanism that operates at the level of mab-5 RNA synthesis or stabilization. We also show that mab-5 contains a homeobox similar to that of the Drosophila Antennapedia gene. This suggests that mab-5 influences cell differentiation and cell migration by regulating gene expression, and clearly demonstrates that genes containing homeoboxes influence global aspects of pattern formation in organisms other than Drosophila.[1]

References

  1. Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox. Costa, M., Weir, M., Coulson, A., Sulston, J., Kenyon, C. Cell (1988) [Pubmed]
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