Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Lapierre, H. et al.

Synergism and diurnal variations of human growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves.

Sixteen male Holstein calves averaging 168 kg body weight (BW) were used to determine the effects of human growth hormone-releasing factor (1-29)NH2 ( hGRF (1-29)NH2; .22 micrograms/kg BW), thyrotropin-releasing factor ( TRF; .165 micrograms/kg BW) or hGRF (1-29)NH2 plus TRF (.22 and .165 micrograms/kg BW, respectively) on growth hormone ( GH) release in animals exposed to 16 hr of light (L): 8 hr of dark (D) (lights on at 0100 hr) and hGRF plus TRF (.22 and .165 micrograms/kg BW, respectively) in animals exposed to 8L:16D (lights on at 0900 hr). For each treatment, times of iv injection were 0400, 1000, 1600 and 2200 hr. In animals exposed to 16L:8D, average GH peaks reached after hGRF (1-29)NH2 or TRF injections were 49.7 and 32.0 ng/ml while the area under the GH response curve (AUC) were 1247 and 1019 ng/ml.min, respectively. There was no significant effect of times of injection on GH release following the separate injection of hGRF(1-29)NH2 or TRF. In animals exposed to 16L:8D, GH peaks and AUC after hGRF plus TRF injections were 226.4, 189.2 and 116.8 ng/ml, and 4340, 3660 and 2415 ng/ml.min at 0400, 1000 and 1600 hr (lights on), respectively but only 42.3 ng/ml and 1692 ng/ml.min at 2200 hr (lights off). In animals exposed to 8L:16D, GH levels and AUC after hGRF plus TRF injections reached 177.5 and 180.5 ng/ml, and 2759 and 3704 ng/ml.min at 1000 and 1600 hr (lights on) but only 84.0 and 72.7 ng/ml, and 1544 and 1501 ng/ml.min at 0400 and 2200 hr (lights off), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)[1]

References

Synergism and diurnal variations of human growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves. Lapierre, H., Petitclerc, D., Pelletier, G., Dubreuil, P., Morisset, J., Gaudreau, P., Couture, Y., Brazeau, P. Domest. Anim. Endocrinol. (1987) [Pubmed]

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