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Synthesis of glycoconjugates derived from various lipopolysaccharides of the Vibrionaceae family.

Conjugation of simple ketoses (such as 3-deoxy-D-manno-2-octulosonic acid and N-acetylneuraminic acid) and of various O-specific polysaccharides (from Aeromonas hydrophila and Aeromonas salmonicida) to the bifunctional spacer 1,6-hexanediamine, was achieved by reductive amination. The saccharide--1-(6-amino)-hexane alkyamines obtained were converted into the corresponding isothiocyanate derivatives and coupled to the free epsilon-amino group of lysine residues of the protein carrier bovine serum albumin. In similar manner, the aldehyde group introduced by selective periodate oxidation into the partially O-deacylated lipopolysaccharide of Vibrio anguillarum was conjugated to 1,6-hexanediamine, converted into the corresponding isothiocyanate and covalently attached to bovine serum albumin.[1]

References

  1. Synthesis of glycoconjugates derived from various lipopolysaccharides of the Vibrionaceae family. Banoub, J.H., Shaw, D.H., Nakhla, N.A., Hodder, H.J. Eur. J. Biochem. (1989) [Pubmed]
 
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