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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.

The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.[1]

References

  1. Effects of angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs. Takada, T., Yamamoto, K., Fujioka, S., Tamaki, T., Fukui, K., Abe, Y. Jpn. J. Pharmacol. (1985) [Pubmed]
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