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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mitozantrone as single agent therapy in hepatocellular carcinoma. A phase II study.

Thirty-five patients with hepatocellular carcinoma ( HCC) have been treated with the Anthracenedione derivative, Mitozantrone. One complete and 5 partial responses were seen in 22 evaluable patients and in a further 4 patients tumour size remained static for lengths of time ranging from 13 to 42 weeks. Therapy was well tolerated. Bone marrow suppression was dose-limiting but easily managed by dose reduction. Other acute toxicity was rare, vomiting and hair loss being reported only once each. Cardiac 'events' occurred in 5 patients, 3 of whom had received high total cumulative doses of Mitozantrone. We conclude that Mitozantrone is of clinical benefit in HCC and that its usage is compatible with a good quality of survival. Its cardiotoxic potential requires further evaluation.[1]

References

  1. Mitozantrone as single agent therapy in hepatocellular carcinoma. A phase II study. Dunk, A.A., Scott, S.C., Johnson, P.J., Melia, W., Lok, A.S., Murray-Lyon, I., Williams, R., Thomas, H.C. J. Hepatol. (1985) [Pubmed]
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