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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein specifically binds to DNA regions containing a single base-pair mismatch. The protein displayed variable affinity for the limited set of mismatches tested (G-T greater than G-A approximately equal to A-C greater than T-C).[1]

References

  1. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Su, S.S., Modrich, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
 
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