The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Incidence and mortality of perioperative myocardial infarction in patients undergoing coronary artery bypass grafting.

The incidence of perioperative myocardial infarction (MI) determined by electrocardiogram was examined in 168 consecutive patients having only coronary artery bypass grafting at Yale-New Haven Hospital from July 1974 to June 1975. The incidence of MI and its mortality were correlated with clinical, hemodynamic, anatomic, and operative factors. Perioperative MI occurred in 23% of all patients (39/168); 26 in the inferior, 11 in the anterior, and two in the anterolateral wall. Three factors appeared related to the occurrence of MI: 1) abrupt propranolol withdrawal 24 hours prior to surgery (Prop) (32%, 33/103); 2) left main coronary artery disease (LMCD) (37%, 7/19); and 3) cardiopulmonary bypass longer than 60 minutes ( CPB) (23%, 30/128). To more precisely predict MI, combinations of factors were examined. The combination of LMCD and CPB was 39%, (7/18) while the absence of either yielded an incidence of only 5.1% (2/39) (P less than 0.001). The mortality of patients with MI was 15.4% (6/39) while in patients without MI the mortality was 1.6% (2/129). We conclude that the risk of perioperative MI is significantly increased by abrupt propranolol withdrawal 24 hours before surgery, left main coronary artery disease, and cardiopulmonary bypass longer than 60 minutes in patients undergoing coronary artery bypass grafting. The mortality of perioperative MI is high, despite previous reports of the benignity of perioperative myocardial infarction.[1]

References

  1. Incidence and mortality of perioperative myocardial infarction in patients undergoing coronary artery bypass grafting. Langou, R.A., Wiles, J.C., Peduzzi, P.N., Hammond, G.L., Cohen, L.S. Circulation (1977) [Pubmed]
 
WikiGenes - Universities