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Berger, H. et al.

Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.

Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.[1]

References

Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts. Berger, H., Wintersberger, E. J. Virol. (1986) [Pubmed]

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