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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen.

A murine recombinant Neo(r) retrovirus encoding the SV40 small t antigen was used to infect Balb/c 3T3 CIA31 cells. From analyses of G418-resistant clones containing at least as much intact t as Cos-1 cells, we found that t, alone, had no detectable A31 transforming activity. In contrast, we noted that SV40 large T promoted A31 agar colony formation when present over a 5- to 7.5-fold concentration range. However, at the low end of the spectrum, its transforming effect was manifest inefficiently except in the presence of t. Thus a major role for t in the SV40 transforming mechanism is to enhance directly or indirectly the transforming function of T.[1]

References

  1. SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Bikel, I., Montano, X., Agha, M.E., Brown, M., McCormack, M., Boltax, J., Livingston, D.M. Cell (1987) [Pubmed]
 
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