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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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S-adenosylmethionine treatment of depression: a controlled clinical trial.

The antidepressant properties of S-adenosylmethionine, an endogenous methyl donor, were studied in inpatients who met the DSM-III criteria for major depression. Nine patients given intravenous S-adenosylmethionine and nine given low oral doses of imipramine were compared in a double-blind design for 14 days. The S-adenosylmethionine produced superior results by the end of the first week of treatment. By the end of the second week, 66% of the S-adenosylmethionine patients had a clinically significant improvement in depressive symptoms, compared to 22% of the imipramine patients. Side effects appeared to be fewer with S-adenosylmethionine than with imipramine during the last 5 days of the study.[1]

References

  1. S-adenosylmethionine treatment of depression: a controlled clinical trial. Bell, K.M., Plon, L., Bunney, W.E., Potkin, S.G. The American journal of psychiatry. (1988) [Pubmed]
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