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Formation of lipoxin B by the pure reticulocyte lipoxygenase.

The pure reticulocyte lipoxygenase converts 5,15-DiHETE via a lipoxygenase reaction to 5,14,15-trihydroxy-6,8,10,12-eicosatetraenoic acid (a lipoxin B isomer) as shown by GC/MS analysis of its trimethylsilyl ether. With arachidonic acid, 15-HETE and 15-HETE methyl ester this lipoxin B isomer was also formed. The results presented here indicate that pure mammalian lipoxygenases are able to form lipoxins via sequential multiple oxygenation of arachidonic acid or its hydroxy derivatives.[1]

References

  1. Formation of lipoxin B by the pure reticulocyte lipoxygenase. Kühn, H., Wiesner, R., Alder, L., Schewe, T., Stender, H. FEBS Lett. (1986) [Pubmed]
 
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