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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The role of methotrexate in osteosarcoma.

High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic issues concerning MTX therapy in osteosarcoma are discussed.[1]

References

  1. The role of methotrexate in osteosarcoma. Grem, J.L., King, S.A., Wittes, R.E., Leyland-Jones, B. J. Natl. Cancer Inst. (1988) [Pubmed]
 
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