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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Response of the mouse femoral muscle to an implant of a composite of bone morphogenetic protein and plaster of Paris.

A composite consisting of 1 mg of bone morphogenetic protein ( BMP) and 5 mg of plaster of Paris (PLP) was implanted into the mouse femoral muscle. Control PLP without BMP was implanted into the contralateral muscle. The BMP/PLP composite induced cartilage formation within two weeks, trabecular bone within three weeks, and lamellar bone including bone marrow within six weeks. PLP did not disturb BMP-induced bone formation. In addition, the BMP/PLP composite was resorbed early after implantation. These results suggest that PLP composite system is one of the most suitable BMP delivery systems currently available.[1]

References

  1. Response of the mouse femoral muscle to an implant of a composite of bone morphogenetic protein and plaster of Paris. Yamazaki, Y., Oida, S., Akimoto, Y., Shioda, S. Clin. Orthop. Relat. Res. (1988) [Pubmed]
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