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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm.

Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya, respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region. Also, we show that intrachromosomal recombination between the Y short arm and Sxr' can sometimes occur during male meiosis, restoring the deleted DNA sequences and resulting in an H-Y+ mouse (male 719 in this paper). Based on these results, we propose a model for the generation of the original Sxr region and the Sxr' and Sxr719 variants.[1]

References

  1. Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm. Roberts, C., Weith, A., Passage, E., Michot, J.L., Mattei, M.G., Bishop, C.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
 
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