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Spolsky, V.W. et al.

Effects of alexidine.2HCL mouthwash on plaque and gingivitis after six months.

Two-hundred and fourteen subjects ranging in age from 22 to 63 years used either a mouthwash that contained 0.035% w/v alexidine.2HCL (2-ethylhexyl bisbiguanidine dihydrochloride) or a placebo twice daily on a doubleblind basis for six months in conjunction with routine oral hygiene procedures. The results indicated that alexidine.2HCL was safe and was statistically more effective in producing a clinically significant reduction in gingivitis than was the placebo.[1]

References

Effects of alexidine.2HCL mouthwash on plaque and gingivitis after six months. Spolsky, V.W., Forsythe, A.B. J. Dent. Res. (1977) [Pubmed]

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