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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences.

DNA-nuclear protein interactions were studied with synthetic recombination signal sequences (RSSs) for immunoglobulin V-J joining. With a gel retardation assay, a DNA-binding protein that specifically interacts with RSSs was detected in nuclear extracts from a pre-B cell line, 38B9. This protein was found in all the recombination-competent pre-B cell lines tested in this study, but not in myeloma, mature T cell, monocyte, or fibroblast cell lines. DNA footprint analysis with dimethyl sulfate demonstrated that the 7-mer region of the RSS was strongly protected when complexed with the binding protein. Furthermore, a single base substitution in the 7-mer region totally abolished the binding. The molecular mechanism of V-J joining is discussed in the context of the RSS-binding protein.[1]

References

  1. A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Aguilera, R.J., Akira, S., Okazaki, K., Sakano, H. Cell (1987) [Pubmed]
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