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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Teratologic evaluation of 2-phenoxyethanol in New Zealand White rabbits following dermal exposure.

2-Phenoxyethanol was applied to the clipped skin of pregnant rabbits on Days 6 through 18 of gestation in order to assess the fetotoxic and teratogenic potential by the dermal route. Rabbits were treated with 0, 300, 600, or 1000 mg/kg/day of 2-phenoxyethanol, and fetuses were examined for external, visceral, and skeletal alterations. Dermal application of 1000 mg/kg/day produced maternal toxicity as evidenced by intravascular hemolysis of red blood cells and death in some animals. Maternal toxicity was observed in rabbits treated with 600 mg 2-phenoxyethanol/kg/day but at a lower incidence than that observed at 1000 mg/kg/day. Nine rabbits in the 1000 mg/kg/day dose group and five rabbits at 600 mg/kg/day died or were sacrificed in extremis. Rabbits in the two highest dose groups which survived until Day 28 of gestation showed no evidence of treatment-related effects. No signs of maternal toxicity were seen at 300 mg/kg/day. Examination of rabbit fetuses indicated that, at the dosages tested, 2-phenoxyethanol was not embryotoxic, fetotoxic, or teratogenic.[1]

References

  1. Teratologic evaluation of 2-phenoxyethanol in New Zealand White rabbits following dermal exposure. Scortichini, B.H., Quast, J.F., Rao, K.S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1987) [Pubmed]
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