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Grönbech, J.E. et al.

Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat.

This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespective of the secretory state of mucosa. Neither pentagastrin nor cimetidine showed any protective effect against mucosal damage produced by 2 M NaCl. Ninety minutes after mucosal exposure to 2 M NaCl there was an almost complete restitution of the gastric surface epithelium in pentagastrin-stimulated and cimetidine-treated animals, whereas about 15% of the gastric surface still showed damage in animals in which acid secretion was not interfered with. These findings show that restitution of the surface epithelium, in vivo, is a rapid and resistant process even at a very low luminal pH. The secretory state of mucosa may have some influence on this process.[1]

References

Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat. Grönbech, J.E., Grong, K., Varhaug, J.E., Lekven, J., Svanes, K. Gastroenterology (1987) [Pubmed]

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