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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of josamycin on polymorphonuclear leucocyte chemotaxis.

The effects of josamycin on the chemotactic response of blood polymorphonuclear leucocytes were studied. After oral administration of 2 g/day or 50 mg/kg/day for five days in man and rats respectively, polymorphonuclear chemotaxis was reduced by 20%. After in-vitro incubation with 10 mg/l josamycin chemotaxis was unaltered, whereas a 15% decrease was noted with 25 mg/l josamycin. These data suggest that josamycin is unlikely to severely impair chemotaxis in patients.[1]

References

  1. Effects of josamycin on polymorphonuclear leucocyte chemotaxis. Eyraud, A., Lombard, J.Y., Descotes, J., Laschi-Loquerie, A., Tachon, P., Veysseyre, C., Evreux, J.C. J. Antimicrob. Chemother. (1986) [Pubmed]
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