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Association between HLA and Sjögren's syndrome in Japanese patients.

Japanese patients with primary Sjögren's syndrome (SS), patients with SS and rheumatoid arthritis (SS- RA), and patients with SS and connective tissue disease without RA (nonrheumatoid connective tissue disease [SS- CTD]) were typed for HLA antigens. Patients with primary SS and those with SS- RA had higher frequencies of DRw53 than did those who had SS- CTD; however, the group with SS- CTD showed a negative correlation with DRw52. These data indicate that Japanese and white patients with SS have different HLA specificities, and that genetic factors involved in the development of SS- CTD might be different from those in primary SS and SS- RA.[1]

References

  1. Association between HLA and Sjögren's syndrome in Japanese patients. Moriuchi, J., Ichikawa, Y., Takaya, M., Shimizu, H., Uchiyama, M., Sato, K., Tsuji, K., Arimori, S. Arthritis Rheum. (1986) [Pubmed]
 
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