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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Association between HLA and Sjögren's syndrome in Japanese patients.

Japanese patients with primary Sjögren's syndrome (SS), patients with SS and rheumatoid arthritis (SS- RA), and patients with SS and connective tissue disease without RA (nonrheumatoid connective tissue disease [SS- CTD]) were typed for HLA antigens. Patients with primary SS and those with SS- RA had higher frequencies of DRw53 than did those who had SS- CTD; however, the group with SS- CTD showed a negative correlation with DRw52. These data indicate that Japanese and white patients with SS have different HLA specificities, and that genetic factors involved in the development of SS- CTD might be different from those in primary SS and SS- RA.[1]


  1. Association between HLA and Sjögren's syndrome in Japanese patients. Moriuchi, J., Ichikawa, Y., Takaya, M., Shimizu, H., Uchiyama, M., Sato, K., Tsuji, K., Arimori, S. Arthritis Rheum. (1986) [Pubmed]
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