A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus.
The role of avidity in the pathogenicity of double-stranded DNA/anti-double-stranded DNA immune complexes in systemic lupus erythematosus ( SLE) has been controversial. We used polyethylene glycol to identify low avidity antibodies and the standard Farr assay to detect high avidity antibodies against double-stranded DNA in a longitudinal study of sera from 19 patients with SLE. We found that high and low avidity antibodies to double-stranded DNA did not move independently, but instead, rose and fell in a parallel and relatively fixed manner in these patients. The mechanisms responsible for the changes in titer of anti-double-stranded DNA antibody appeared nondiscriminatory in regard to avidity. In addition, the humoral immune response in SLE depicted by these antibody measurements appeared atypical, lacking maturational features.[1]References
- A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus. McGrath, H., Biundo, J.J. Arthritis Rheum. (1985) [Pubmed]
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