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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Treatment selection for stage IIIA Hodgkin's disease patients.

Two treatment policies for the therapy of patients with Stage IIIA Hodgkin's disease are compared. From 1969-1976, 49 newly diagnosed and pathologically staged IIIA patients received total nodal irradiation (TNI) alone (no liver irradiation). Although actuarial survival was 80% at 5 years and 68% at 10 years, actuarial freedom from relapse was only 38% at 5 years. Accordingly, a new treatment policy was instituted in 1976. Patients with either CS IIIA disease, multiple splenic nodules, IIIA with a large mediastinal mass or III2, received combined modality therapy (combination chemotherapy and irradiation). All others received TNI. Thirty-six patients have been treated under the new program. The actuarial survival is 90% at 5 years and the relapse-free survival is 87%, suggesting the superiority of this approach.[1]

References

  1. Treatment selection for stage IIIA Hodgkin's disease patients. Prosnitz, L.R., Cooper, D., Cox, E.B., Kapp, D.S., Farber, L.R. Int. J. Radiat. Oncol. Biol. Phys. (1985) [Pubmed]
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