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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Selective loss of a family of gene transcripts in a hereditary murine cataract.

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous gamma crystallins encoded by a family of gamma-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of gamma-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in gamma-crystallin coding sequences.[1]

References

  1. Selective loss of a family of gene transcripts in a hereditary murine cataract. Garber, A.T., Winkler, C., Shinohara, T., King, C.R., Inana, G., Piatigorsky, J., Gold, R.J. Science (1985) [Pubmed]
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