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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of intracerebroventricular 3-mercaptopropionic acid on blood pressure and heart rate in the rat.

Intracerebroventricular (i.c.v.) injection of 3-mercaptopropionic acid (3-MP, 250 micrograms/10 microliter) elicited an elevation of blood pressure in a dose-dependent manner in anaesthetized rats. This elevation of blood pressure could be blocked by treatment with amino-oxyacetic acid (AOAA, 25 mg/kg, i.p.) 5 h prior to the i.c.v. injection of 3-MP. Given intraperitoneally (i.p.), 3-MP (75 mg/kg) had no effect on blood pressure or heart rate. I.c.v. injection of 3-MP produced a selective decrease in GABA content in the diencephalon and mesencephalon, whereas i.p. injection of 3-MP caused a decrease in GABA content in all regions of brain, including telencephalon, diencephalon, mesencephalon, pons and medulla. The results suggest that the elevation of blood pressure induced by i.c.v. injection of 3-MP may be the result of a selective depletion of GABA in diencephalon and/or mesencephalon. Decreases in GABA content in brain regions other than diencephalon and mesencephalon may lead to an opposite effect in modulating blood pressure.[1]


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