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Delatour, P. et al.

Comparative pharmacokinetics of febantel and its metabolites in sheep and cattle.

The pharmacokinetics of febantel and its main metabolites were studied in cattle and sheep. Seven ewes and 4 heifers were given febantel orally in a single dose of 7.5 mg/kg, 25 mg/kg, or 45 mg/kg of body weight. Plasma concentrations vs time of febantel and individual metabolites were determined by high-performance liquid chromatography analysis. Intestinal absorption of febantel was faster and biotransformations were more active in sheep than in cattle.[1]

References

Comparative pharmacokinetics of febantel and its metabolites in sheep and cattle. Delatour, P., Tiberghien, M.P., Garnier, F., Benoît, E. Am. J. Vet. Res. (1985) [Pubmed]

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